The Armenian National Committee of America (ANCA) is the largest and most influential Armenian American grassroots political organization. ANCA aims to educate, motivate, and activate individuals to take action on various issues such as Armenian Genocide, Artsakh (Nagorno Karabakh), US-Armenia ties, US-Turkey relations, and advocacy for legislative initiatives. The organization offers ways to donate, participate in advocacy efforts, attend events, volunteer, join the ANCA E-List, register to vote, and apply for internships and scholarships. ANCA also provides a platform for media engagement with news updates, photos, and videos related to their activities.

The ANCA has different regional headquarters in locations like Washington DC, Watertown MA, and Glendale CA. They focus on empowering communities and expanding Armenian American civic engagement through grassroots development efforts led by individuals like Gev Iskajyan as the national grassroots director. Additionally, the organization engages with legislators to secure justice for Artsakh and the Armenian Genocide while advocating for issues such as the safe return of Armenians to Artsakh and holding Azerbaijan accountable for its actions.